Heat-Shock Proteins and Photodynamic therapy.
Baylis*, Craig A. Downs~,
R. Jones* Scott A. Heckathorn~
|*Department of Physics
|~Department of Biology
College of Charleston,
Many cancer treatments, such as photodynamic
therapy, generate active
oxygen species, often in the mitochondria. These oxygen species
react with cellular processes, thereby destroying cancer cells and
Heat-shock proteins are up-regulated in response to heat stress of
envoronmental stresses and are known to protect cells from active oxygen
species. In tumor cells, heat-shock proteins are responsible
increased resistance of cancer cells to oxidative-based anti-cancer
therapies. We will first determine which heat-shock proteins
the mitochondria of cancer cells (lung carcinomas). We will determine
the over-expression of specific heat-shock proteins in the mitochondria
protect cells from Photofrin-mediated photodynamic therapy through
protection of mitochondrial electron transport.
Bulletin of the American Physical Society November 1998.
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